The Use Of Nicotinic Acid In The Treatment Of Heart Disease. Part 3 of 3

The Use Of Nicotinic Acid In The Treatment Of Heart Disease – Part 3 of 3

Did the fault lie with the laropiprant and not niacin? Armitage is doubtful. She pointed to a prior trial, called AIM-HIGH, which was discontinued initially in 2011 when researchers found no benefit to niacin treatment. At the time, some experts said that the smaller population in AIM-HIGH masked any sign of benefit, but Armitage said the inexperienced trial’s much bigger study group confirms that niacin probably does not help.

Speaking in February 2013 at the time of the journal’s release of niacin’s safety profile, one US expert was less than impressed by niacin’s performance. The suffering “confirms that, for the present moment, there may be little additional benefit with the use of niacin when patients are well treated with the lipid-lowering statin drugs,” said Dr Kevin Marzo, principal of cardiology at Winthrop-University Hospital in Mineola, NY. He said that the results of the new trial, along with those from a prior large study, “now may put the final nail in the coffin on niacin-based strategies to get together HDL and lower cardiovascular events”.

Other tried-and-true approaches may work best. “In addition to statins, our focus should be on continued lifestyle changes such as a Mediterranean diet, complemented with everyday exercise”. The US Food and Drug Administration had been waiting on the new trial results to decide whether to approve niacin/laropiprant for use against heart disease view homepage. But in December 2012, responding to beginning findings, drug maker Merck said it no longer planned to press for approval from the FDA and in January 2013 delayed niacin/laropiprant from markets worldwide.

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The Use Of Nicotinic Acid In The Treatment Of Heart Disease. Part 2 of 3

The Use Of Nicotinic Acid In The Treatment Of Heart Disease – Part 2 of 3

They received either 2 grams of extended-release niacin addition 40 milligrams of laropiprant or matching placebos. All of the patients also took Zocor (simvastatin). The patients from China, the United Kingdom and Scandinavia were followed for an usual of almost four years.

patients

Besides showing no helpful effect on heart health outcomes, the team noted that people taking niacin had about the same amount of heart-related events (13,2 percent) as those who took a placebo as an alternative (13,7 percent). Side effects were common. As already reported online Feb 26, 2013 in the European Heart Journal, by the end of the study, 25 percent of patients taking niacin together with laropiprant had stopped their treatment, compared with 17 percent of the patients taking a placebo.

And “The main reason for patients stopping the healing was because of adverse side effects, such as itching, rashes, flushing, indigestion, diarrhea, diabetes and muscle problems,” Armitage said at the time in a journal news release. “We found that patients allocated to the experiential treatment were four times more likely to stop for skin-related reasons, and twice as likely to stop because of gastrointestinal problems or diabetes-related problems”. Patients taking niacin and laropiprant had a more than fourfold increased gamble of muscle pain or weakness compared to the placebo group, the team noted.

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The Use Of Nicotinic Acid In The Treatment Of Heart Disease. Part 1 of 3

The Use Of Nicotinic Acid In The Treatment Of Heart Disease – Part 1 of 3

The Use Of Nicotinic Acid In The Treatment Of Heart Disease. Combining the vitamin niacin with a cholesterol-lowering statin medicine appears to sell patients no benefit and may also increase side effects, a new study indicates. It’s a disappointing result from the largest-ever study of niacin for heart patients, which involved almost 26000 people. In the study, patients who added the B-vitamin to the statin panacea Zocor saw no added benefit in terms of reductions in heart-related death, non-fatal heart attack, stroke, or the need for angioplasty or go surgeries.

The study also found that people taking niacin had more incidents of bleeding and (or) infections than those who were taking an inactive placebo, according to a team reporting Saturday at the annual meeting of the American College of Cardiology, in San Francisco. “We are discontented that these results did not show benefits for our patients,” study lead author Jane Armitage, a professor at the University of Oxford in England, said in a meeting news release. “Niacin has been second-hand for many years in the belief that it would help patients and prevent heart attacks and stroke, but we now know that its adverse side effects outweigh the benefits when used with current treatments”.

Niacin has long been utilized to boost levels of “good” HDL cholesterol and decrease levels of “bad” LDL cholesterol and triglycerides (fats) in the blood in people at risk for heart disease and stroke. However, niacin also causes a legions of side effects, including flushing of the skin. A drug called laropiprant can reduce the incidence of flushing in people taking niacin. This new study included patients with narrowing of the arteries.

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Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles. Part 3 of 3

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles – Part 3 of 3

Palmer said he didn’t see the new technology as a replacement for Botox, but instead as an alternative for masses who don’t want an injection of a neurotoxin. The company will eventually seek FDA approval as a medical device. Palmer said the company might first seek approval in Europe.

Dr Brian Zelickson, an companion professor of dermatology at the University of Minnesota in Minneapolis, said the technique sounds promising, but needs more research to determine how long results last and to make sure no lasting effrontery or muscle injury occurs that could cause permanent changes in sensation. He agreed that the toxin-free cosmetic procedure might win some followers.

So “Botox and Dysport are very easy, very quick, the patient satisfaction outline is great and there are very few side effects,” said Zelickson, incoming president of ASLMS. “It’s a high bar to leap over, but there are some people that don’t like the concept of injecting Botulinum toxin into their bodies. If there were a routine that could be done, that doesn’t inject any chemical into the system and could yield the same results for the same duration, there is a market for that” sex tolar tips. According to the American Society for Aesthetic Plastic Surgery, Botox and Dysport injections tip their list of nonsurgical procedures.

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Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles. Part 2 of 3

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles – Part 2 of 3

The art does not permanently damage the nerve. Researchers said they are still refining the technique and could not say how long the effect lasts, but it seems to be comparable to Botox, which works for about three to four months. Physicians would for training to identify the nerve that should be targeted.

researchers

The 15-minute treatment is done using local anesthesia, according to the researchers. The current study only looks at forehead wrinkles; future research will study the standard operating procedure elsewhere on the face. For the study, researchers tried the technique on 31 people, all of whom had fewer wrinkles after two to eight injections. The most common side effects were headaches and scrape redness.

The level of discomfort was comparable to that from Botox or fillers. But unlike Botox, which takes a few days to kick in, the effects of the cryotechnology are seen immediately, the researchers say. Because this con was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

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Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles. Part 1 of 3

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles – Part 1 of 3

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles. A recent technology that temporarily zaps away forehead wrinkles by freezing the nerves shows warranty in early clinical trials, researchers say. The technique, if eventually approved by the US Food and Drug Administration, could provide an alternative to Botox and Dysport. Both are injectable forms of Botulinum toxin genus A, a neurotoxin that, when injected in small quantities, temporarily paralyzes facial muscles, thereby reducing wrinkles. “It’s a toxin-free selection to treating unwanted lines and wrinkles, similar to what is being done with Botox and Dysport,” said study co-author Francis Palmer, director of facial plastic surgery at the University of Southern California School of Medicine in Los Angeles.

And “From the prematurely clinical trials, this procedure – which its maker calls cryoneuromodulation – appears to have the same clinical efficacy and safety comparable to the existing techniques”. Palmer is also consulting medical governor of MyoScience Inc, the Redwood City (California) – based company developing the cryotechnology. The results of the clinical trials were to be presented Friday at an American Society for Laser Medicine and Surgery (ASLMS) discussion in Grapevine, Texas.

To do the procedure, physicians use small needles – “cryoprobes” – to deliver cold to nerves perpetual through the forehead, specifically the temporal branch of the frontal nerve. The cold freezes the nerve, which interrupts the nerve signal and relaxes the muscle that causes vertical and horizontal forehead lines. Although the presumption quickly returns to normal body temperature, the cold temporarily “injures” the nerve, allowing the signal to remain interrupted for some period of time after the patient leaves the office.

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Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles. Part 3 of 3

Cryoneedles A Possible Alternative To Botox In Fighting Against Wrinkles – Part 3 of 3

Palmer said he didn’t see the new technology as a replacement for Botox, but instead as an alternative for kin who don’t want an injection of a neurotoxin. The company will eventually seek FDA approval as a medical device. Palmer said the company might first seek approval in Europe.

Dr Brian Zelickson, an partner professor of dermatology at the University of Minnesota in Minneapolis, said the technique sounds promising, but needs more research to determine how long results last and to make sure no lasting resoluteness or muscle injury occurs that could cause permanent changes in sensation. He agreed that the toxin-free cosmetic procedure might win some followers.

So “Botox and Dysport are very easy, very quick, the patient satisfaction limn is great and there are very few side effects,” said Zelickson, incoming president of ASLMS. “It’s a high bar to leap over, but there are some people that don’t like the concept of injecting Botulinum toxin into their bodies. If there were a scheme that could be done, that doesn’t inject any chemical into the system and could yield the same results for the same duration, there is a market for that” maxgenics. According to the American Society for Aesthetic Plastic Surgery, Botox and Dysport injections peerless their list of nonsurgical procedures.

Parts: 1 2 3

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